Diurnal variation in peak expiratory flow rate among workers exposed to toluene diisocyanate in the polyurethane foam manufacturing industry.
نویسندگان
چکیده
The diurnal variation in peak expiratory flow rate (PEFR) was studied in 26 mixers from eight factories making polyurethane foam, who were exposed to toluene diisocyanate (TDI), and 26 unexposed controls matched for age, race, and smoking. They were all men. The mean diurnal variation in PEFR of the mixers was 6.2%, which was significantly higher than the 4.3% for controls. Six mixers had a diurnal variation of greater than 15% on at least one day compared with none among the controls. There was, however, no overt cause of occupational asthma. All but one of the 24 environmental samples taken exceeded the short term exposure limit of 0.02 ppm for TDI. This accounted for the high prevalence (50%) of irritative symptoms such as cough and eye irritation. Forced expiratory volume in one second (FEV1) and FEV1/forced vital capacity (FVC) (%) was negatively correlated with duration of exposure to TDI. Foam workers may still have high exposure to TDI, high prevalence of irritative symptoms, increased diurnal variation in PEFR and evidence of chronic airway obstruction, particularly in those with greater than or equal to 10 years of exposure.
منابع مشابه
Cancer incidence and mortality of isocyanate exposed workers from the Swedish polyurethane foam industry: updated findings 1959-98.
AIMS To assess whether cancer incidence and mortality in chronic obstructive lung diseases were increased in the Swedish polyurethane foam industry cohort, updated with 11 more years of follow up. METHODS The mortality and cancer incidence (1959-98) experienced by a cohort of 4175 male and female employees employed for at least one year in the period 1959-87 at one of nine Swedish polyurethan...
متن کاملToluene diisocyanate-linked ocupational airflow obstruction and peak expiratory flow rate patterns among foam makers
متن کامل
بررسی تاثیر 1،6 هگزامتیلن دی ایزوسیا نات بر نتایج تست پیک فلومتری در کارگران کارگاههای رنگ کاری اتومبیل شهر اصفهان
Abstract Background & Aims: Hexamethylene diisocyanate is an aliphatic isocyanate and car painters are exposed to it. One of the most important disorders is occupational asthma. The aim of this study was to survey the effect of 1, 6 hexamethylene diisocyanate on the peak expiratory flow test to car painters in Isfahan. Materials & Methods: In this descriptive and a cross-sectional study the f...
متن کاملارزیابی ریسک مواجهه شغلی با مواد شیمیایی به منظور ارائه راهکارهای کنترلی (مطالعه موردی در یک صنعت فوم پلی اورتان)
Background: In the foam industries, workers are exposed to various chemicals and working with these chemicals without considering occupational safety and health considerations could lead to different harmful symptoms. Consequently, in order to control measures and reducing risk to acceptable level, it is necessary to assess the health risk of exposure to harmful chemicals by implementation of s...
متن کاملProtein adducts as biomarkers of exposure to aromatic diisocyanates in workers manufacturing polyurethane (PUR) foam.
This work was undertaken to investigate the usefulness of diisocyanate-related protein adducts in blood samples as biomarkers of occupational exposure to toluene diisocyanate (TDI; 2,4- and 2,6-isomers) and 4,4'-methylenediphenyl diisocyanate (MDI). Quantification of adducts as toluene diamines (TDAs) and methylenedianiline (MDA) was performed on perfluoroacylated derivatives by gas chromatogra...
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ورودعنوان ژورنال:
- British journal of industrial medicine
دوره 49 6 شماره
صفحات -
تاریخ انتشار 1992